Bile Acids in Neurodegenerative Disorders
نویسندگان
چکیده
منابع مشابه
Bile Acids in Neurodegenerative Disorders
Bile acids, a structurally related group of molecules derived from cholesterol, have a long history as therapeutic agents in medicine, from treatment for primarily ocular diseases in ancient Chinese medicine to modern day use as approved drugs for certain liver diseases. Despite evidence supporting a neuroprotective role in a diverse spectrum of age-related neurodegenerative disorders, includin...
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neurodegenerative disorders such as huntingtons disease, alzheimers disease, parkinsons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, friedreichs ataxia, and others are multi-factorial illnesses in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. thus, presently there are no effective cures for these disease...
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BACKGROUND Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration--implantation of viable cells as a therapeutical approach. DISCUSSION Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished...
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Type 2 transglutaminase (TG2) is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TG2 is likely to play a modulatory role in nervous system development and has regulator...
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In a recent paper Foster and Hoop& (1) have described a rapid method for the estimation of bile acids in dog bile. The method depends on the fact that the two bile acids usually found in dog bile, viz. taurocholic and taurocholeic, on hydrolysis with alkali give taurine, which yields its nitrogen quantitatively in 4 minutes when shaken with HN02. Taurocholic and taurocholeic acids do not react ...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2016
ISSN: 1663-4365
DOI: 10.3389/fnagi.2016.00263